Mediator Head module structure and functional interactions
نویسندگان
چکیده
منابع مشابه
Structure of the Mediator subunit Cyclin C and subunit interaction studies within the Mediator head module
Diese Dissertation wurde selbständig und ohne unerlaubte Hilfe erarbeitet. Acknowledgements I want to thank Patrick Cramer for everything that I learned during my PhD in his lab, especially for giving me the opportunity to work as independent as possible. are the four fellows who shared this whole time with me, I´m very glad that I met them and grateful for their understanding friendship. Sonja...
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The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for ...
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Ehrenwörtliche Versicherung Diese Dissertation wurde selbstständig und ohne unerlaubte Hilfe erarbeitet. " I am among those who think that science has great beauty. A scientist in his laboratory is not only a technician: he is also a child placed before natural phenomena which impress him like a fairy tale. We should not allow it to be believed that all scientific progress can be reduced to mec...
متن کاملThe Mediator head module and regulation of RNA polymerase II transcription initiation
Acknowledgements " Coming together is a beginning. Keeping together is progress. Working together is success. " This quote describes very well the multidisciplinary and collaborative atmosphere at the Gene Center in Munich. Therefore I am very glad to have decided to do my PhD thesis in the laboratory of Prof. Patrick Cramer. First of all, I would like to thank my supervisor Prof. Patrick Crame...
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The successful synthesis of a transcript by RNA polymerase II (RNAPII) is a multistage process with distinct rate-limiting steps that can vary depending on the particular gene. A growing number of genes in a variety of organisms are regulated at steps after the recruitment of RNAPII. The best-characterized Saccharomyces cerevisiae gene regulated in this manner is CYC1. This gene has high occupa...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2010
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.1757